Abstract
Cyclosporine is an immunosuppressant drug that suppresses effectively the immune response, and main drug used to
prevent rejection in organ transplantation. Negative impact in the oral cavity of cyclosporine therapy is characterized
by the occurrence of gingival enlargement in 8-70% of cases, which occurred in the first 3-6 months of use, as well as
the loss of alveolar bone. The effect of the drug on gingival enlargement is a serious problem in patients receiving
cyclosporine therapy. Pathogenesis of gingival enlargement on cyclosporine therapy is not known at all, but the
influence of fibroblast proliferation and extracellular matrix were estimated reduction capabilities play a role in this
aspect. Dental plaque does not have a significant relationship to the occurrence of gingival enlargement on
cyclosporine therapy, but support the occurrence of chronic inflammation that contributes to gingival enlargement.
Adequate oral hygiene with initial periodontal treatment can reduce inflammation and gingival enlargement due to
cyclosporine therapy. Patients who will undergo organ transplantation, previously had to undergo dental and oral
health care comprehensively.
Recommended Citation
Aranti, Rifi and Kemal, Yulianti
(2013)
"Efek samping pada rongga mulut akibat terapi siklosporin Side effect in oral cavity due to cyclosporine therapy,"
Dentofasial: Vol. 12:
Iss.
1, Article 4.
DOI: 10.15562/jdmfs.v12i1.349
Available at:
https://scholarhub.unhas.ac.id/dentofasial/vol12/iss1/4
Pages
49-53
Rights
©2016Rifi Aranti, Yulianti Kemal
DOI
10.15562/jdmfs.v12i1.349