Abstract
Microbicidal mechanism with producing free radical superoxide is one of neutrophil response to the bacterial
invasion. When overproducted, the free radical superoxide greater than antioxidan defense system and destroyed the
cell itself. P.gingivalis had been knowed as the major bacteria that induce periodontal inflammation. These bacteria
can stimulated neutrophil activities. This was aimed to determinate the superoxide production from neutrophil
stimulated with P.gingivalis. Neutrophil as samples were isolated from subject who fulfill the selected criteria. The
intracelluler superoxide production was determinated by nitroblue tetra zolium (NBT)test and the extracelluler
production by spectrophotometer with wave length 580 nm. The result showed there was superoxide production from
neutrophil stimulated by P.gingivalis. It was concluded that the stimulation of P.gingivalis on neutrophil can promote
superoxide production both intracelluler and extracelluler.
Recommended Citation
Fitriyana, Nahdiya; Arina, Yuliana MD; Harmono, Happy; and Susilawati, IDA
(2013)
"The effect of Porphyromonas gingivalis induction on neutrophil’s superoxide production,"
Dentofasial: Vol. 12:
Iss.
3, Article 8.
DOI: 10.15562/jdmfs.v12i3.370
Available at:
https://scholarhub.unhas.ac.id/dentofasial/vol12/iss3/8
Pages
152-158
Rights
©2016Nahdiya Fitriyana, Yuliana MD Arina, Happy Harmono, IDA Susilawati
DOI
10.15562/jdmfs.v12i3.370