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Abstract

Squamous cell carcinoma at the tongue is a malignant tumor derived from epithelial mucosa of the oral cavity. This
study aims to identify and to analyze the effect of flavonoid fraction of etanol of ant nests plants (Myrmecodia pendans)as an anti-cancer barrier against the proliferation of SP-C1 tongue cancer cells. The study was conducted with pure
experimental laboratory methods using Supri's-Clone 1 (SP-C1) human tongue cancer cells cultured. Research
gradually begins with determination, extraction and fractionation ant nests plant, cytotoxicity test to get a fraction of
flavonoids that have anticancer potential,and finaly testing the proliferation barriers. Cytotoxicity test showed that
from the highest concentration (1000 μg/mL) to the lowest concentration (7.8125 μg/mL) in etanol fraction, fraction
hexan and water caused Sp-C1 human tongue cancer cells death significantly. Ethanol fraction LC
values of 938,003.
These results were obtained from the linear equivalent of the relation between log consentration and probit. Flavonoid
etanol fraction of ant nest has an inhibition effect against proliferation of SP-C1. Antiproliferative analysis of flavonoid
fraction of ethanol flavonoid based on concentration and incubation time on optical density absorbation SP-C1 cells
was statistically highly significant (p=0.00).

Pages

1-6

Rights

©2016Harun Achmad, Supriatno Supriatno, Marhamah Marhamah, Rasmidar Rasmidar

DOI

10.15562/jdmfs.v13i1.378

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