Efek pegagan (Centella asiatica L)terhadap proliferasi mesenchymal stem cell (Effect of pegagan (Centella asiatica L)to mesenchymal stem cell proliferation)

Authors

Ira Arundina, Department of Oral Biology Faculty of Dentistry, Airlangga University Surabaya, IndonesiaFollow
Ketut Suardita, Department of Dental Conservative Faculty of Dentistry, Airlangga University Surabaya, IndonesiaFollow

Abstract

Stem cells provide new hope to fasten the healing process of various oral diseases including periodontal tissue
(periodontitis). At present time, there is not yet found a material that can fix the teeth perfectly. Adult stem cells from
bone marrow widely used for treatment. Numbers of stem cell are limited so growth factor is necessary to promote
proliferation of stem cells. Growth factor that has been used is expensive and difficult to get. Because of these
constraints, it is necessary to develop alternative uses of medicinal plants as growth factor that accelerates wound
healing process. This study is aimed to proven what extent the potential Pegagan (Centella asiatica L) as a natural
growth factors to stem cells. The ability of proliferation and osteogenic differentiation in mesenchymal stem cells
(MSC)was analyzed by adding terpenoid fraction of Centella asiatica. MTT assay data showed that the addition of
Pegagan on cultured MSCs can increase stem cell proliferation. Pegagan increases the ability of MSC proliferation
and differentiate into osteoblasts It is concluded that pegagan increase the ability of MSC proliferation and
differentiate into osteoblasts.

Recommended Citation

Arundina, Ira and Suardita, Ketut (2014) "Efek pegagan (Centella asiatica L)terhadap proliferasi mesenchymal stem cell (Effect of pegagan (Centella asiatica L)to mesenchymal stem cell proliferation)," Dentofasial: Vol. 13: Iss. 1, Article 5.
DOI: 10.15562/jdmfs.v13i1.386
Available at: https://scholarhub.unhas.ac.id/dentofasial/vol13/iss1/5

Pages

43-47

Rights

©2016Ira Arundina, Ketut Suardita

DOI

10.15562/jdmfs.v13i1.386