Abstract
Background: This editorial review systematically examines the current issue of The Journal of Dentomaxillofacial Science, highlighting the growing importance of biocompatible materials and plant-based extracts in dental regenerative therapies.
Method: Modulation of growth factors, including VEGF, FGF-2, and TGF-β, is crucial for improving tissue repair and regeneration in dental treatments. The studies reviewed show that combining plant extracts, such as galam leaf, with tricalcium silicate cement enhances growth factor expression and promotes angiogenesis, odontoblast differentiation, and fibroblast proliferation.
Results: Modulation of growth factors significantly accelerated tissue healing and regeneration. The integration of biocompatible materials and plant-based extracts has a significant potential for enhancing regenerative therapies in dentistry. Promising areas include the use of Piladang leaf extract for chronic periodontitis, mackerel bone gelatin for mandibular bone healing, and hydroxyapatite-cassava starch scaffolds for bone grafts. The review also discusses treatment adherence in patients with cleft lip and palate, the role of platelet-rich fibrin in bone grafting, and the potential of black soybean extract for gingivitis.
Conclusions: Methodological strengths include rigorous experimental designs and advanced analytical techniques, whereas limitations involve variability in animal models and experimental protocols. Future research should focus on longitudinal studies assessing long-term efficacy and safety and exploring the synergistic effects of combining different materials and growth factors to optimize healing outcomes. The integration of natural plant-derived compounds with traditional dental biomaterials has emerged as a promising approach to enhance the outcomes of dental regenerative therapies.
Recommended Citation
Ikbal, Muhammad; Hasanuddin, H.; Mude, Acing H.; Marlina, Erni; and Ruslin, Muhammad
(2025)
"Plant-based extracts and biocompatible materials in dental tissue regeneration: An editorial review,"
Journal of Dentomaxillofacial Science: Vol. 10:
Iss.
3, Article 1.
DOI: https://doi.org/10.15562/jdmfs.v10i3.2115
Available at:
https://scholarhub.unhas.ac.id/jdmfs/vol10/iss3/1
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Rights
©2025Muhammad Ikbal, H. Hasanuddin, Acing H. Mude, Erni Marlina, Muhammad Ruslin
DOI
10.15562/jdmfs.v10i3.2115