Abstract
Objective: This study aims to determine the benefits of gum arabic as an immunomodulatory and antibacterial drug therapy in the oral cavity of diabetic mellitus rats.
Material and Methods: Male wistar rats induced by diabetes mellitus accompanied by periodontitis and Gum Arabic therapy. This study was divided into 5 treatment groups, namely group I (control), group II (diabetes mellitus) and group III (diabetes mellitus and periodontitis with P. gingivalis injection), group IV (diabetes mellitus treated with gum arabic), group V (diabetes mellitus with periodontitis and treated with gum arabic). The parameters studied were TNF-α anti-inflammatory mediators and the number of colonies of periodontopathogenic bacteria.
Results: Decreased expression of TNF-α and the number of bacterial colonies in the treatment group of both diabetes mellitus with periodontitis and diabetes alone treated with Gum arabic.
Conclusion: Gum arabic therapy proved effective as an immunomodulatory, anti-inflammatory and antibacterial in DM rats and periodontitis
Keywords: Diabetes mellitus, Gum arabic, Periodontitis, TNF-α
Recommended Citation
Ermawati, Tantin; Suhartini; Indriana, Tecky; and Hamzah, Zahreni
(2025)
"Capacity of gum arabic as immunomodulator and antibacterial agent against oral cavity periodontopathogen in diabetes mellitus rats with periodontitis,"
Journal of Dentomaxillofacial Science: Vol. 10:
Iss.
3, Article 16.
DOI: https://doi.org/10.15562/jdmfs.v10i3.1524
Available at:
https://scholarhub.unhas.ac.id/jdmfs/vol10/iss3/16
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
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©2025Tantin Ermawati, Suhartini, Tecky Indriana, Zahreni Hamzah
DOI
10.15562/jdmfs.v10i3.1524