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Abstract

Objective: This study aims to analyze dinicopathological and radiographic predictors of recurrence inpatients with ameloblastoma treated at a national referral hospital in Indonesia.

Material and Method: This cross-sectional study was conducted at Dr. Cipto Mangunkusumo Hospital (RSCM), a national referral center in Jakarta, Indonesia. A total of 163 patients with histopathologically confirmed ameloblastoma were treated between January 2014 and December 2024. Patients who did not undergo surgical treatment or had incomplete records were excluded from the analysis. Demographic and clinicopathological parameters were analyzed for their association with tumor recurrence using thechi-square test, Fisher's exact test, and binary logistic regression.

Results: The study had a mean age of 34.2 years, with the majority of patients aged 20-45 years (62.0%). The majority of tumors arose in the mandible (92.6%) and showed multilocular lesions (85.9%). Recurrence rate was 29.4%. Multivariate analysis revealed that radical surgical treatment was strongly associated with a lower recurrence rate (OR 0.013, 95% Cl 0.004--0.041; p<0.001), while a multilocular radiographic appearance significantly increased the recurrence risk (OR 6.368, 95% Cl1.256-32.288, p = 0.025). Although locularity was not significant in univariate analysis, it became important in multivariate modeling, suggesting a potential interaction with the surgical modality.

Conclusion: Both surgical approach and locularity are significant predictors of ameloblastoma recurrence. These findings support individualized treatment planning based on risk stratification.

Pages

30

DOI

10.65844/2503-0825.1477

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