Abstract
Objective: Alveolar bone resorption is a physiological process that leads to a pathological state, often seen as an oral symptom of inflammation in periodontitis. Turmeric (Curcuma longa Linn) is considered to have anti-inflammatory properties that can help decrease inflammation in periodontitis. Turmeric's curcumin component offers several biological advantages for the body. However, turmeric has a limitation due to its poor absorption in the digestive system. A chemically modified curcumin agent, known as cmc2.24, was created to be more effective than natural curcumin molecules. Methods: PubMed, Embase, and Medline electronic databases were searched for research publications on chemically modified curcumin's role in preventing alveolar bone loss in periodontitis. Results CMC2.24 successfully decreased NF-κB and p38 MAPK, leading to a reduction in pro-inflammatory cytokines and MMPs. Radiographic studies demonstrated that therapy with CMC2.24 decreased alveolar bone resorption. Conclusions: The chemically modified curcumin compound CMC2.24 effectively reduced inflammatory signaling and alveolar bone resorption in periodontitis. Further clinical research is needed to fully evaluate the therapeutic potential of CMC2.24 for preventing and treating alveolar bone loss in patients with periodontal disease.
Keywords: Curcumin, CMC2.24, inflammatory mediators, alveolar bone resorption, periodontitis
Recommended Citation
Adam, Mardiana; Gani, Asdar; and Manggalatung, Lea J.
(2024)
"Benefits of turmeric (Curcuma longa Linn) in inhibiting alveolar bone resorption in periodontitis: A scoping review,"
Journal of Dentomaxillofacial Science: Vol. 9:
Iss.
2, Article 4.
DOI: https://doi.org/10.15562/jdmfs.v9i2.1751
Available at:
https://scholarhub.unhas.ac.id/jdmfs/vol9/iss2/4
Pages
70-77
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Rights
©2024Andi M. Adam, Asdar Gani, Supiyati, Lea J. Manggalatung
DOI
10.15562/jdmfs.v9i2.1751