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Abstract

Objective. The objective of this study was to quantify the number of macrophages and fibroblasts involved in the post dental extraction socket healing.

Material and Methods. Chitosan BSF pupae was made into a gel preparation. Eighteen Male Cavia cobaya were divided into two groups (n = 9), control and treatment groups. BSF pupae chitosan gel was applied to the post-extraction tooth socket in the treatment group, while none was applied to the control group. The samples were decapitated on the 2nd, 3rd, and 5th days by cutting the mandibular bone for histopathological examination, which was carried out by measuring the number of macrophages and fibroblasts through microscopic observation and data analysis.

Results. An increase in macrophages was evident in the treatment group on the 2nd and 3rd days, while a decrease was seen on the 5th day. There was an increase in fibroblasts on the 2nd, 3rd, and 5th days. Kruskal Wallis test indicated a significant difference in macrophages between the control and the treatment group with p = 0.006 (p < 0.05), and the One-way ANOVA test indicated a significant difference in fibroblasts between both groups with p = 0.000 (p < 0.05).

Conclusion. The application of chitosan BSF pupae accelerates the post-extraction wound healing process in Cavia cobaya by increasing the number of macrophages on the 2nd and 3rd days, decreasing on the 5th day, and also increasing the number of fibroblasts which may be good for accelerate wound healing process.

Pages

166-171

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

Rights

©2024Renie K. Dewi; Sri Oktawati, Asdar Gani, Eko Suhartono, Zakiah H. Noor, Nurlinda Hamrun, Shahida M. Said, Beta W. Oktiani

DOI

10.15562/jdmfs.v9i3.1680

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