Molecular pathways of odontogenic keratocysts: A systematic review

Authors

Paolo Boffano, Department of Otolaryngology, DeAzienda USL della Valle d'Aosta, Aosta, ItalyFollow
Francesca Neirotti, University of Eastern Piedmont, Novara, ItalyFollow
Matteo Brucoli, University of Eastern Piedmont, Novara, ItalyFollow
Muhammad Ruslin, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Hasanuddin University, Makassar, IndonesiaFollow

Abstract

The odontogenic keratocyst (OKC) stands out as one of the most prevalent odontogenic tumors. Since its initial description, numerous studies have delved into various aspects of this lesion, aiming to unravel its distinctive biological behavior.

Recent investigations have specifically focused on the molecular aspects of OKC, shedding light on its biological characteristics. Substantial differences at the molecular level between OKC and other odontogenic cystic lesions indicate a distinct biological origin. Genetic and molecular research in the realm of odontogenic tumors, particularly OKC, has contributed significantly to the growing knowledge and understanding of their physiopathological pathways. The molecular findings may open non-surgical, pharmaceutical options for treatment. This systematic review aims to identify the molecular aspects of odontogenic keratocysts that have been elucidated to date

Recommended Citation

Boffano, Paolo; Neirotti, Francesca; Brucoli, Matteo; and Ruslin, Muhammad (2024) "Molecular pathways of odontogenic keratocysts: A systematic review," Journal of Dentomaxillofacial Science: Vol. 9: Iss. 3, Article 2.
DOI: https://doi.org/10.15562/jdmfs.v9i3.1929
Available at: https://scholarhub.unhas.ac.id/jdmfs/vol9/iss3/2

Pages

151-155

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Rights

©2025Paolo Boffano, Francesca Neirotti, Matteo Brucoli, Muhammad Ruslin

DOI

10.15562/jdmfs.v9i3.1929